Hydrochloric Acid → 1-(4-(2-Carbamoylpyridin-4-yloxy)-2,5-difluorophenyl)-3-(2-(4-fluorophenyl)acetyl)urea
Reaction equation
[CH2:76]1[O:77][CH2:78][CH2:79][CH2:80]1.[CH:20]([N:21]([CH:22]([CH3:23])[CH3:24])[CH2:25][CH3:26])([CH3:27])[CH3:28].[ClH:29].[F:63][c:64]1[cH:65][cH:66][c:67]([CH2:70][C:71](=[O:72])[N:73]=[C:74]=[O:75])[cH:68][cH:69]1.[NH2:1][c:2]1[cH:3][c:4]([F:19])[c:5]([O:6][c:7]2[cH:8][c:9]([C:13](=[O:14])[NH2:15])[n:10][cH:11][cH:12]2)[cH:16][c:17]1[F:18].[NH2:30][c:31]1[cH:32][c:33]([O:34][c:35]2[cH:36][cH:37][c:38]([NH:39][C:40](=[O:41])[CH2:42][C:43]([NH:44][CH:45]([c:46]3[cH:47][cH:48][cH:49][cH:50][cH:51]3)[C:52]([O:53][CH3:54])=[O:55])=[O:56])[cH:57][c:58]2[F:59])[cH:60][cH:61][n:62]1>>[NH:1]([c:2]1[cH:3][c:4]([F:19])[c:5]([O:6][c:7]2[cH:8][c:9]([C:13](=[O:14])[NH2:15])[n:10][cH:11][cH:12]2)[cH:16][c:17]1[F:18])[C:74]([NH:73][C:71]([CH2:70][c:67]1[cH:66][cH:65][c:64]([F:63])[cH:69][cH:68]1)=[O:72])=[O:75]Participants
7
Reactant 6
HCID 313Hydrochloric Acid
HCID 8028Tetrahydrofuran
HCID 81531Diisopropylethylamine
HCID 231530882-(4-Fluorophenyl)acetyl isocyanate
HCID 247886284-(4-Amino-2,5-difluorophenoxy)pyridine-2-carboxamide
HCID 60209274Methyl 2-[[3-[4-[(2-amino-4-pyridinyl)oxy]-3-fluoroanilino]-3-oxopropanoyl]amino]-2-phenylacetateProduct 1
Sources & evidence
- ORD record
- ord-004df101fba144ff8adae8dd59cf195b
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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