Diisopropylamine → 2,2,4,4-Tetramethyl-6-ethynylchroman

HRID 835307Notes

Reaction equation

HRID 835307 reaction equation
[CH2:30]([O:31][P:32]([Cl:33])([O:34][CH2:35][CH3:36])=[O:37])[CH3:38].[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:13][C:14]1([CH3:29])[O:15][c:16]2[cH:17][cH:18][c:19]([C:26]([CH3:27])=[O:28])[cH:20][c:21]2[C:22]([CH3:24])([CH3:25])[CH2:23]1.[CH3:52][CH2:53][CH2:54][CH2:55][CH2:56][CH3:57].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[CH:39]([N-:40][CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[Li+:46]>>[CH3:13][C:14]1([CH3:29])[O:15][c:16]2[cH:17][cH:18][c:19]([C:26]#[CH:27])[cH:20][c:21]2[C:22]([CH3:24])([CH3:25])[CH2:23]1

Participants

9

Reactant 8

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8058HexaneHCID 13139Diethyl chlorophosphateHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 156611361-(2,2,4,4-Tetramethyl-3,4-dihydro-2H-1-benzopyran-6-yl)ethan-1-oneHCID 178418339Butyllithium

Product 1

HCID 156611382,2,4,4-Tetramethyl-6-ethynylchroman

Sources & evidence

ORD record
ord-636474385968427a953cf2bf8e710ef9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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