Hydrochloric Acid → 5-Bromo-2-(2,6-dimethyl-morpholin-4-yl)-3,4-difluoro-benzaldehyde

HRID 836266Notes

Reaction equation

HRID 836266 reaction equation
[Br:1][c:2]1[c:3]([F:12])[c:4]([F:11])[c:5]([F:10])[c:6]([CH:7]=[O:8])[cH:9]1.[CH3:13][CH2:14][N:15]([CH2:16][CH3:17])[CH2:18][CH3:19].[CH3:20][CH:21]1[O:22][CH:23]([CH3:27])[CH2:24][NH:25][CH2:26]1.[CH3:29][C:30]#[N:31].[ClH:28]>>[Br:1][c:2]1[c:3]([F:12])[c:4]([F:11])[c:5]([N:25]2[CH2:24][CH:23]([CH3:27])[O:22][CH:21]([CH3:20])[CH2:26]2)[c:6]([CH:7]=[O:8])[cH:9]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 8471TriethylamineHCID 1108622,6-DimethylmorpholineHCID 735543605-Bromo-2,3,4-trifluorobenzaldehyde

Product 1

HCID 866145005-Bromo-2-(2,6-dimethyl-morpholin-4-yl)-3,4-difluoro-benzaldehyde

Sources & evidence

ORD record
ord-d044338bfbe34ad8b82aad061b7cfa5a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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