Hydrochloric Acid → 3-(3,5-Difluorophenoxy)-5-(1,3-dioxolan-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indazole
Reaction equation
[C:24](=[O:25])([O-:26])[O-:27].[CH2:47]1[O:48][CH2:49][CH2:50][O:51][CH2:52]1.[CH3:31][N:32]([CH3:33])[CH2:34][C:35]([OH:36])=[O:37].[ClH:30].[Cs+:28].[Cs+:29].[Cu:53][I:54].[F:38][c:39]1[cH:40][c:41]([OH:46])[cH:42][c:43]([F:45])[cH:44]1.[O:1]1[CH:2]([c:6]2[cH:7][c:8]3[c:9]([I:23])[n:10][n:11]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[c:12]3[cH:13][cH:14]2)[O:3][CH2:4][CH2:5]1>>[O:1]1[CH:2]([c:6]2[cH:7][c:8]3[c:9]([O:46][c:41]4[cH:40][c:39]([F:38])[cH:44][c:43]([F:45])[cH:42]4)[n:10][n:11]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[c:12]3[cH:13][cH:14]2)[O:3][CH2:4][CH2:5]1Participants
9
Reactant 8
HCID 313Hydrochloric Acid
HCID 673N,N-Dimethylglycine
HCID 19660Carbonate Ion
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 312751,4-Dioxane
HCID 759283,5-Difluorophenol
HCID 104967Cesium cation2×
HCID 584076045-(1,3-Dioxolan-2-yl)-3-iodo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indazoleProduct 1
Sources & evidence
- ORD record
- ord-69bb7e4cb33d486ebcfe9b3841818f52
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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