Hydrochloric Acid → 1-(3-((4-(Ethylsulfonyl)piperazin-1-yl)methyl)-2-fluorophenyl)-3-(2-methylpyridin-4-yl)urea

HRID 837680Notes

Reaction equation

HRID 837680 reaction equation
[CH2:41]([CH3:42])[S:43](=[O:44])(=[O:45])[Cl:46].[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH3:47][OH:48].[Cl:49][CH2:50][Cl:51].[ClH:33].[F:1][c:2]1[c:3]([CH2:4][N:5]2[CH2:6][CH2:7][N:8]([C:11]([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:17])[CH2:9][CH2:10]2)[cH:18][cH:19][cH:20][c:21]1[NH:22][C:23](=[O:24])[NH:25][c:26]1[cH:27][c:28]([CH3:32])[n:29][cH:30][cH:31]1>>[F:1][c:2]1[c:3]([CH2:4][N:5]2[CH2:6][CH2:7][N:8]([S:43]([CH2:41][CH3:42])(=[O:44])=[O:45])[CH2:9][CH2:10]2)[cH:18][cH:19][cH:20][c:21]1[NH:22][C:23](=[O:24])[NH:25][c:26]1[cH:27][c:28]([CH3:32])[n:29][cH:30][cH:31]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 8471TriethylamineHCID 11667Ethanesulfonyl chlorideHCID 58919226Tert-butyl 4-(2-fluoro-3-(3-(2-methylpyridin-4-yl)ureido)benzyl)piperazine-1-carboxylate

Product 1

HCID 236417451-(3-((4-(Ethylsulfonyl)piperazin-1-yl)methyl)-2-fluorophenyl)-3-(2-methylpyridin-4-yl)urea

Sources & evidence

ORD record
ord-3e6283f67ff8417b833b5195a8c3ce8c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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