Chloride → Methyl 2-acetoxy-3-(2-(methoxymethyl)-7-methyl-2H-indazol-5-yl)acrylate

HRID 837909Notes

Reaction equation

HRID 837909 reaction equation
[C:1]([CH3:2])(=[O:3])[O:4][CH:5]([C:6](=[O:7])[O:8][CH3:9])[P:10]([CH2:11][CH3:12])([CH2:13][CH3:14])=[O:15].[CH3:18][NH:19][C:20](=[N:21][CH3:22])[N:23]([CH3:24])[CH3:25].[CH3:26][O:27][CH2:28][n:29]1[n:30][c:31]2[c:32]([CH3:40])[cH:33][c:34]([CH:38]=[O:39])[cH:35][c:36]2[cH:37]1.[Cl-:17].[Li+:16].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1>>[C:1]([CH3:2])(=[O:3])[O:4][C:5]([C:6](=[O:7])[O:8][CH3:9])=[CH:38][c:34]1[cH:33][c:32]([CH3:40])[c:31]2[n:30][n:29]([CH2:28][O:27][CH3:26])[cH:37][c:36]2[cH:35]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 141618N,N,N',N''-TetramethylguanidineHCID 577946242-(Methoxymethyl)-7-methyl-2H-indazole-5-carbaldehydeHCID 86599652Methyl 2-acetoxy-2-(diethylphosphoryl)acetate

Product 1

HCID 68460956Methyl 2-acetoxy-3-(2-(methoxymethyl)-7-methyl-2H-indazol-5-yl)acrylate

Sources & evidence

ORD record
ord-34ceb22e867f4c2593764f3a43b37c6f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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