Hydrochloric Acid → 2-(4-Fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyridazin-3-yl)cyclo propylcarbamoyl)phenyl)benzofuran-3-carboxamide

HRID 838107Notes

Reaction equation

HRID 838107 reaction equation
[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[ClH:41].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[o:9][c:10]3[c:11]([c:12]2[C:13]([NH:14][CH3:15])=[O:16])[cH:17][c:18](-[c:21]2[cH:22][c:23]([C:24](=[O:25])[OH:26])[cH:27][cH:28][c:29]2[CH3:30])[cH:19][cH:20]3)[cH:6][cH:7]1.[O:49]=[CH:50][N:51]([CH3:52])[CH3:53].[n:31]1[n:32][c:33]([C:37]2([NH2:40])[CH2:38][CH2:39]2)[cH:34][cH:35][cH:36]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[o:9][c:10]3[c:11]([c:12]2[C:13]([NH:14][CH3:15])=[O:16])[cH:17][c:18](-[c:21]2[cH:22][c:23]([C:24](=[O:26])[NH:40][C:37]4([c:33]5[n:32][n:31][cH:36][cH:35][cH:34]5)[CH2:38][CH2:39]4)[cH:27][cH:28][c:29]2[CH3:30])[cH:19][cH:20]3)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 592756533-(2-(4-Fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-4-methylbenzoic acidHCID 672914811-(Pyridazin-3-yl)cyclopropanamine

Product 1

HCID 595051552-(4-Fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyridazin-3-yl)cyclo propylcarbamoyl)phenyl)benzofuran-3-carboxamide

Sources & evidence

ORD record
ord-077758e3e5734abd86e93857d3193bbe
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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