Hydrochloric Acid → 1,2,3-Propanetricarboxylic acid, 1-phosphono-

HRID 838829Notes

Reaction equation

HRID 838829 reaction equation
C[O:2][P:3]([CH:7]([C:18]([O:20]C)=[O:19])[CH:8]([C:14]([O:16]C)=[O:15])[CH2:9][C:10]([O:12]C)=[O:11])(=[O:6])[O:4]C.Cl.CCl>CO>[C:18]([CH:7]([P:3]([OH:4])(=[O:2])[OH:6])[CH:8]([C:14]([OH:16])=[O:15])[CH2:9][C:10]([OH:12])=[O:11])([OH:20])=[O:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6327Methyl ChlorideHCID 54201759HCID 54201759, compound

Product 1

HCID 99649781,2,3-Propanetricarboxylic acid, 1-phosphono-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The ester thus obtained and 100 cc of concentrated hydrochloric acid were heated to boiling temperature (which increased from 75° to 105° C) while methyl chloride and methanol originating from the hydrolysis were distilled off. After the hydrolysis was complete, the reaction solution was evaporated under vacuum to dryness (maximum base temperature = 120° C) and diluted with water so as to obtain a solution of 50% strength.

Workup

  1. distillationwere distilled off
  2. customthe reaction solution was evaporated under vacuum to dryness (maximum base temperature = 120° C)
  3. additiondiluted with water so as
  4. customto obtain a solution of 50% strength

Sources & evidence

ORD record
ord-059c3305a2cc4429914beaf6d52a8a9f
Source dataset
uspto-grants-1978_06
Patent number
US04093538

Reaction notes

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