Hydrochloric Acid → HCID 70619331, compound

HRID 838966Notes

Reaction equation

HRID 838966 reaction equation
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:6]2[N:7]([CH3:10])[CH:8]=[N:9][C:5]=2[CH:4]=1.[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)=[O:21].COCCO.[ClH:33]>C(O)(C)C>[ClH:33].[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:6]2[N:7]([CH3:10])[C:8]([N:25]3[CH2:26][CH2:27][N:22]([C:20]([C:16]4[O:15][CH:19]=[CH:18][CH:17]=4)=[O:21])[CH2:23][CH2:24]3)=[N:9][C:5]=2[CH:4]=1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 80192-MethoxyethanolHCID 5502061-(2-Furoyl)piperazineHCID 754984HCID 754984, compound

Product 1

HCID 70619331HCID 70619331, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

3.50 g. 2-chloro. 5,6-dimethoxy-1-methyl benzimidazole [(J. Org. Chem. USSR 1 1466), (1965)] 7.00 g N-(2-furoyl) piperazine, and 25 ml 2-methoxyethanol were reacted as described in Example I. The product was converted to its hydrochloride by dissolving in isopropyl alcohol and acidifying with a solution of HCl gas in isopropyl alcohol. Yield: 3.99 g product, mp 212°-215° C decomp.

Sources & evidence

ORD record
ord-510d2c2837754ab290925241ceab50fa
Source dataset
uspto-grants-1978_06
Patent number
US04093726

Reaction notes

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