Hydrochloric Acid → HCID 86735738, compound

HRID 838968Notes

Reaction equation

HRID 838968 reaction equation
[Cl:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:5]=2[N:6]=1.[CH3:15][N:16]([CH3:25])[C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18].COC(O)C.Cl>C(O)(C)C>[ClH:1].[CH3:15][N:16]([CH3:25])[C:17]([N:19]1[CH2:20][CH2:21][N:22]([C:2]2[NH:3][C:4]3[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:5]=3[N:6]=2)[CH2:23][CH2:24]1)=[O:18]

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 712909n,n-Dimethylpiperazine-1-carboxamideHCID 30156371-MethoxyethanolHCID 20325524HCID 20325524, compound

Product 1

HCID 86735738HCID 86735738, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3.50 g 2-chloro 5,6-dimethoxybenzimidazole, 7.50 g N,N-dimethyl 1-piperazine carboxamide [J. Org. Chem. 13 144 (1948)], 20 ml methoxyethanol was reacted as described in Example I. The product was converted to the HCl salt with HCl in isopropyl alcohol. Yield: 5.33 g mp 252°-254° C (85%)

Sources & evidence

ORD record
ord-3d84d1c841dd4f3db11611c4337f9e5d
Source dataset
uspto-grants-1978_06
Patent number
US04093726

Reaction notes

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