反应详情

温度

-5 °C

Phenyl magnesium bromide is prepared from 14.5 g. of magnesium turnings and 80 g. of bromobenzene in 200 ml. of dry ether. the Grignard solution is cooled to -5° C, and a solution of 71 g. of 2-methyl-propiophenone in 100 ml. of ether is added under vigorous stirring. The mixture is refluxed for 15 minutes, thereafter cooled, and the Grignard complex is decomposed with an aqueous solution of ammonium chloride under cooling. The ethereal phase is separated, washed with water until neutral, and dried over anhydrous magnesium sulfate. The solvent is evaporated, and the residue is subjected to fractional distillation. This way 84.7 g. of 2-methyl-α-ethyl-benzhydrol are obtained; b.p.: 109°-113° C 0.05-0.1 mmHg.

1. temperatureThe mixture is refluxed for 15 minutes
2. temperaturecooled
3. temperatureunder cooling
4. customThe ethereal phase is separated
5. washwashed with water until neutral, and
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent is evaporated
8. distillationthe residue is subjected to fractional distillation