反应详情

温度

110 °C

A mixture of the compound obtained from step f above (1.0 g) (4-chlorophenyl)boronic acid (0.76 g), tetrakis(triphenylphosphine)palladium (0) (0.14 g), and potassium carbonate (1.0 g) in dry dimethylformamide (10 mL) was heated at 110° C. for 4 hours. Ethyl acetate and water were added to the reaction mixture. The organic layer was separated, washed with water and brine solution, and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure to obtain a residue which was purified by column chromatography over silica gel using 12% ethyl acetate in hexane as eluant to afford the title compound (0.9 g).

1. customThe organic layer was separated
2. washwashed with water and brine solution
3. dry with materialdried over anhydrous sodium sulphate
4. customThe solvent was evaporated under reduced pressure
5. customto obtain a residue which
6. customwas purified by column chromatography over silica gel using 12% ethyl acetate in hexane as eluant