Hydrochloric Acid → HCID 15406934, compound

HRID 840256Notes

Reaction equation

HRID 840256 reaction equation
[CH3:1][C:2]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].[Li+].[OH-].O.Cl>CCO>[CH3:8][C:2]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)([CH3:1])[C:3]([OH:5])=[O:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 10488027HCID 10488027, compound

Product 1

HCID 15406934HCID 15406934, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
25 °C

Procedure

Ethyl α,α-dimethyl-3-pyridylacetate (disclosed in EP application 0 288 279, published Oct. 26, 1988) (2.67 grams, 13.8 mmoles) was dissolved in EtOH (11.1 ml.) and a 1.0M LiOH in water (33.3 ml.) (33.4 mmoles) was added. The mixture was stirred at 25° C. for 4 hours. 1 N HCl (38.73 ml.) was added and after 5 minutes the mixture was evaporated to dryness to give the title compound (Yield: 100%).

Workup

  1. customwas evaporated to dryness

Sources & evidence

ORD record
ord-276d83f8d5c246c888e8357864494c2c
Source dataset
uspto-grants-2002_04
Patent number
US06365588B1

Reaction notes

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