Potassium Carbonate → HCID 22619862, compound

HRID 840552Notes

Reaction equation

HRID 840552 reaction equation
[CH3:1][C:2]1[C:7]([O:8][C:9]2[N:14]=[N:13][C:12]([C:15]([NH:17][NH2:18])=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[N:19]([O-])=O.[Na+].C(=O)([O-])[O-].[K+].[K+]>Cl.O>[CH3:1][C:2]1[C:7]([O:8][C:9]2[N:14]=[N:13][C:12]([C:15]([N:17]=[N+:18]=[N-:19])=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 23668193Sodium NitriteHCID 70105671HCID 70105671, compound

Product 1

HCID 22619862HCID 22619862, compoundYield 51%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent2×

Procedure

A solution of 6-(2-methylpyridin-3-yloxy)-pyridazine-3-carboxylic acid hydrazide (D12) (0.62 g, 2.53 mmol) in conc. hydrochloric acid (9 ml) and water (7.5 ml) cooled to 0° C. in an ice-bath was treated with a solution of sodium nitrite (0.18 g, 2.53 mmol) in water (1.5 ml) dropwise keeping the temperature below 5° C. After 10 minutes saturated potassium carbonate was added until basic. The precipitate was filtered off, washed with water and air dried to give a cream solid (0.33 g, 51%).

Workup

  1. customthe temperature below 5° C
  2. filtrationThe precipitate was filtered off
  3. washwashed with water and air
  4. customdried

Sources & evidence

ORD record
ord-a5bd18a8795447d7bec32e81b928db39
Source dataset
uspto-grants-2002_04
Patent number
US06369060B1

Reaction notes

Loading…