Oxalyl chloride → HCID 178444536, compound

HRID 840743Notes

Reaction equation

HRID 840743 reaction equation
C(Cl)(=O)C(Cl)=O.[CH2:7]([C@H:12]1[CH2:17][CH2:16][C@H:15]([C:18]([OH:20])=O)[CH2:14][CH2:13]1)[CH2:8][CH2:9][CH2:10][CH3:11].NC1C=CC([C:28]2[NH:29][C:30]3[CH:36]=[CH:35][C:34](N)=[CH:33][C:31]=3[N:32]=2)=CC=1>CN(C=O)C.N1C=CC=CC=1>[CH2:7]([C@H:12]1[CH2:13][CH2:14][C@H:15]([C:18]([C:28]2[NH:29][C:30]3[CH:36]=[CH:35][CH:34]=[CH:33][C:31]=3[N:32]=2)=[O:20])[CH2:16][CH2:17]1)[CH2:8][CH2:9][CH2:10][CH3:11]

Participants

6

Reactant 3

HCID 65578Oxalyl chlorideHCID 178444557HCID 178444557, compoundHCID 178507432HCID 178507432, compound

Product 1

HCID 178444536HCID 178444536, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 1049PyridineSolvent

Procedure

Bis-trans-4-pentylcyclohexyl carbonyl benzimidazole was synthesized as follows: oxalyl chloride (1.07 ml, 2 M in CH2Cl2) was added to trans-4-pentylcyclohexyl carboxylic acid (0.424 g, 2.14 mmole) followed by one drop DMF. The mixture was allowed react at RT for 1 hour. To the above solution was added 2-(4-aminophenyl)-6-amino-benzimidazole (0.200 g, 0.89 mmole) in pyridine (2 ml). The

Workup

  1. customThe mixture was allowed react at RT for 1 hour

Sources & evidence

ORD record
ord-af425a41012c4e28bec7720c521208cc
Source dataset
uspto-grants-2002_04
Patent number
US06369091B1

Reaction notes

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