Hydrochloric Acid → HCID 178472622, compound

HRID 840787Notes

Reaction equation

HRID 840787 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][N:7]1[CH:12]=[CH:11][N:10](C(OCC2C=CC=CC=2)=O)[C@@H:9]([CH2:23][CH2:24][C:25]([NH:27][CH2:28][NH:29][S:30]([C:33]2[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][CH:34]=2)(=[O:32])=[O:31])=[NH:26])[C:8]1=[O:40])=[O:5])[CH3:2].Cl>C(O)C.[OH-].[OH-].[Pd+2]>[CH2:1]([O:3][C:4](=[O:5])[CH2:6][N:7]1[CH2:12][CH2:11][NH:10][C@@H:9]([CH2:23][CH2:24][C:25]([NH:27][CH2:28][NH:29][S:30]([C:33]2[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][CH:34]=2)(=[O:31])=[O:32])=[NH:26])[C:8]1=[O:40])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178472629HCID 178472629, compound

Product 1

HCID 178472622HCID 178472622, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

A solution of the compound of Example 9 (0.43 mmol) in absolute ethanol (10 mL) was treated with Pd(OH)2 (46 mg, 0.086 mmol) and concentrated HCl (1 mL). The mixture was hydrogenated in a PARR shaker at 40 p.s.i. for 5 h. The mixture was filtered through Celite to remove the catalyst and the filtrate was evaporated under reduced pressure to give the title compound.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. customto remove the catalyst
  3. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-3abea8241ca8433dace354d5835260fe
Source dataset
uspto-grants-2002_04
Patent number
US06369063B1

Reaction notes

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