Anisole → HCID 18400084, compound

HRID 841115Notes

Reaction equation

HRID 841115 reaction equation
C([NH:5][S:6]([C:9]1[C:10]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:22]3[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[C:17]([Cl:36])[CH:16]=2)=[CH:11][CH:12]=[CH:13][CH:14]=1)(=[O:8])=[O:7])(C)(C)C.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[Cl:36][C:17]1[CH:16]=[C:15]([C:10]2[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:20]=[CH:19][C:18]=1[CH2:21][N:22]1[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]1[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

4

Reactant 2

HCID 7519AnisoleHCID 17775489HCID 17775489, compound

Product 1

HCID 18400084HCID 18400084, compoundYield 111.5%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1.5 g of 3′-chloro-4′-(4-chloro-5-formyl-2-phenylimidazol-1-ylmethyl)biphenyl-2-sulfonic acid tert-butylamide and 340 μl of anisole are dissolved in 10 ml of trifluoroacetic acid and stirred at RT for 24 h. The volatile constituents are removed in vacuo, the residue is taken up twice with 50 ml of toluene each time and the volatile constituents are again removed in vacuo. 1.5 g of a colorless foam are obtained.

Workup

  1. customThe volatile constituents are removed in vacuo
  2. customthe volatile constituents are again removed in vacuo

Sources & evidence

ORD record
ord-461b42e3c92a49368b0075507df7b3f1
Source dataset
uspto-grants-2002_04
Patent number
US06369236B1

Reaction notes

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