反应详情

A mixture of 4-chloro-5-nitro-2-phenylpyrimidine (3 g), ethylamine hydrochloride (1.6 g), triethylamine (3.9 g) and isopropanol (60 ml) is refluxed for three hours. The reaction mixture is concentrated under reduced pressure, and to the residue are added chloroform and water. The chloroform layer is separated, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (eluent; chloroform), and recrystallized from isopropanol to give the desired compound (2.9 g).

1. temperatureis refluxed for three hours
2. concentrationThe reaction mixture is concentrated under reduced pressure
3. additionto the residue are added chloroform and water
4. customThe chloroform layer is separated
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue is purified by silica gel column chromatography (eluent; chloroform)
8. customrecrystallized from isopropanol