Benzyl Chloride → 1-Bromo-4-phenylmethoxybenzene

HRID 843033Notes

Reaction equation

HRID 843033 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)C=O.C(OC1C=CC(OB(O)O)=CC=1)C1C=CC=CC=1.[Br:36]C1C=CC(O)=CC=1.C(Cl)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>>[CH2:11]([O:10][C:9]1[CH:8]=[CH:7][C:4]([Br:36])=[CH:3][CH:2]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

6

Reactant 5

HCID 7503Benzyl ChlorideHCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 153891394-Benzyloxyphenylboric acidHCID 225590823-Bromo-4-cyclohexylmethyloxybenzaldehyde

Product 1

HCID 1388351-Bromo-4-phenylmethoxybenzene

Procedure

The intermediate 32 (1.76 g), 4-benzyloxyphenyl boric acid [6.75 g, 4-benzyloxy bromobenzene was prepared according to a process described in the process c-1 in example 1 from 4-bromophenol (Tokyo Chemical Ind. Co., Ltd.) and benzyl chloride (Tokyo Chemical Ind. Co., Ltd.), and the product was prepared according to a method described in the reference Y Satoh et al. SYNTHESIS page 1146, 1994], anhydrous potassium carbonate (4.09 g) and tetrakis (triphenylphosphine)palladium (0)(342 mg) were reacted according to the method described in the process i in example 23 to obtain the compound in the title (2.30 g).

Workup

  1. customthe product was prepared
  2. customwere reacted
  3. customto obtain the compound in the title (2.30 g)

Sources & evidence

ORD record
ord-6b84389881e34620a6fc5bc7e27c64ee
Source dataset
uspto-grants-2002_04
Patent number
US06376546B1

Reaction notes

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