Water → HCID 22616533, compound

HRID 843034Notes

Reaction equation

HRID 843034 reaction equation
[CH3:1][N:2]([CH3:26])[C:3]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][C:16]([O:18]C)=[O:17])=[CH:9][C:8]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:4].C(N(CC)CC)C.O.O1CCCC1>CO.C(Cl)(Cl)Cl>[CH3:26][N:2]([CH3:1])[C:3]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:9][C:8]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:4]

Participants

7

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 22616586HCID 22616586, compound

Product 1

HCID 22616533HCID 22616533, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6212ChloroformSolvent

Procedure

The compound in the title (366 mg) was obtained by reacting the intermediate 62 (455 mg) with triethylamine (2.0 ml) in the mixture of purified water (2 ml) and tetrahydrofuran (10 ml) according to the process described in the process a in example 1. Proviso that the reaction was carried out for 10 days. Rf 0.60 (chloroform:methanol=10:1)

Workup

  1. customThe compound in the title (366 mg) was obtained

Sources & evidence

ORD record
ord-b30643359b994ef1aa144d753e01b06a
Source dataset
uspto-grants-2002_04
Patent number
US06376546B1

Reaction notes

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