反应详情

4-Allyloxy-3-methyl-benzofuran-2-carboxylic acid amide (3370 mg) in tetrahydrofuran (60 ml) was treated with sodium bicarbonate (5.58 g) and ethyl bromopyruvate (2.20 ml) followed by trifluoroacetic anhydride (5.63 ml) to give 2-(4-allyloxy-3-methyl-benzofuran-2-yl)-oxazole-4-carboxylic acid ethyl ester as a white solid [2443 mg, EI-MS: m/z 327 (M+)] as mentioned in Example 77.