Water → HCID 22617171, compound

HRID 843365Notes

Reaction equation

HRID 843365 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]=[C:14](Cl)[C:15]([F:18])([F:17])[F:16].Cl.[CH3:21][NH:22][CH3:23].C(N(CC)CC)C.O>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]=[C:14]([N:22]([CH3:23])[CH3:21])[C:15]([F:18])([F:17])[F:16]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 10473Dimethylamine, hydrochlorideHCID 22617159HCID 22617159, compound

Product 1

HCID 22617171HCID 22617171, compoundYield 79.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

First, 0.34 g (1.0 mmol) of N-(2,6-dichloro-4-trifluoromethylphenyl)-2,2,2-trifluoroacetoimidoyl chloride was dissolved in 10 ml of N,N-dimethylformamide, to which 0.08 g (1.0 mmol) of dimethylamine hydrochloride and 0.22 g (2.0 mmol) of triethylamine, and the mixture was stirred at room temperature for 3 hours. Water was poured into the reaction mixture, which was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to give 0.28 g of N′-(2,6-dichloro-4-trifluoromethylphenyl)-2,2,2-trifluoro-N,N-dimethylacetamidine (hereinafter referred to as present compound 52).

Workup

  1. extractionwas extracted with ethyl acetate
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-728c08bd387f40dcba5d14c998146c50
Source dataset
uspto-grants-2002_04
Patent number
US06376710B2

Reaction notes

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