反应详情

温度

-30 °C

To a solution of trimethylsilylacetylene (1715 ml) in tetrahydrofuran (18.0 l) was added ethyl magnesium chloride (2.0M solution in tetrahydrofuran; 6.19 l) was added dropwise below −30° C. under nitrogen atmosphere. The reaction mixture was allowed to 0° C. and stirred for 1 hour. After cooling to −30° C., 4-acetoxy-2-azetidinone (320 g) was added and warmed to room temperature, and stirred for 2 hours. After cooling to −20° C., saturated ammonium chloride (4.0 l) was added. Ethyl acetate (20 l) was added and washed with water (10 l×2) and brine. The organic layer was dried over magnesium sulfate, filtered off and evaporated in vacuo to give 4-(2-trimethylsilylethynyl)-2-azetidinone (425 g), which was essentially pure, so it was used to the next step without further purification.

1. additionwas added dropwise below −30° C. under nitrogen atmosphere
2. customwas allowed to 0° C.
3. temperaturewarmed to room temperature
4. stirringstirred for 2 hours
5. temperatureAfter cooling to −20° C.
6. washwashed with water (10 l×2) and brine
7. dry with materialThe organic layer was dried over magnesium sulfate
8. filtrationfiltered off
9. customevaporated in vacuo