Ethyl Acetate → HCID 53698862, compound

To a stirred solution of lithium aluminum hydride (0.73 g, 19.24 mmol, 2.2 equivalents) in anhydrous tetrahydrofuran (20 mL) at 0° C. was added dropwise a solution of (R)-1-(N-benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene (2.30 g, 8.80 mmol) in anhydrous tetrahydrofuran (20 mL). The resulting reaction mixture was heated at reflux under nitrogen for 3.5 hours. The resulting mixture was then cooled, and sodium sulfate decahydrate (10 g) was added slowly with caution. This mixture was stirred at room temperature under nitrogen for 1 hour, and then ethyl acetate (100 mL) and water (1 mL) was added. The resulting mixture was stirred at room temperature under nitrogen overnight. The mixture was then filtered through Celite®, and the filtrate was evaporated under reduced pressure. Column chromatography of the residual oil using silica gel (approximately 200 g) and elution with methylene chloride/methanol/ammonium hydroxide (9:1:0.1) afforded the title compound (1.13 g, 8.00 mmol, 91%) as a clear, colorless liquid: 13C NMR (CDCl3) δ 132.6, 132.5, 69.0, 62.7, 56.6, 40.2, 31.8, 22.1; Anal. calcd for C8H18NO·0.175 H8NO [ammonium hydroxide]: C, 64.21; H, 10.88; N, 11.34. Found: C, 65.01; H, 10.71; N, 10.81.

1. customThe resulting reaction mixture
2. temperaturewas heated
3. temperatureat reflux under nitrogen for 3.5 hours
4. temperatureThe resulting mixture was then cooled
5. stirringThe resulting mixture was stirred at room temperature under nitrogen overnight
6. filtrationThe mixture was then filtered through Celite®
7. customthe filtrate was evaporated under reduced pressure
8. washsilica gel (approximately 200 g) and elution with methylene chloride/methanol/ammonium hydroxide (9:1:0.1)

ORD record

ord-46ac4aaeb64d482db5f7a11e59336501

Source dataset

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06380233B1