Lithium Hydroxide → HCID 510684, compound

HRID 844354Notes

Reaction equation

HRID 844354 reaction equation
C([O:3][C:4](=[O:31])[C:5](=[O:30])[CH2:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N:15]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:10]=1)=[O:8])C.[Li+].[OH-]>C1COCC1>[CH2:23]([N:15]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:10]=[C:9]([C:7](=[O:8])[CH2:6][C:5](=[O:30])[C:4]([OH:31])=[O:3])[CH:14]=[CH:13][CH:12]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 57006866HCID 57006866, compound

Product 1

HCID 510684HCID 510684, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a similar manner to example AI-2-1, 4-(3-dibenzylaminophenyl)-2,4-dioxobutanoic acid ethyl ester (0.489 g, 1.1 mmol) was reacted with 3 ml 1N LiOH in 10 ml THF to yield 0.4 g (94%) of AV-3-1 as an orange resin. 1H NMR (400 MHz, CDCl3) δ4.71 (s, 4H), 6.96 (dt, 1H, J=7.33, 2.20 Hz).

Workup

  1. customto yield 0.4 g (94%) of AV-3-1 as an orange resin

Sources & evidence

ORD record
ord-3a68cfb266c34ba1be1b3069875bb5f1
Source dataset
uspto-grants-2002_04
Patent number
US06380249B1

Reaction notes

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