反应详情

2.43 g of 5-methyl-2-indolecarboxylic acid are dissolved in 15 ml of DMF; 2.11 g of DBU are added and the mixture is then left stirring for 1 hour at RT. 2.61 g of benzyl bromide are added dropwise and the mixture is then left stirring for 6 hours at RT. This mixture is concentrated under vacuum and the residue is taken up in EtOAc, washed with water, with saturated Na2CO3 solution, with sulphate buffer and then with saturated aqueous NaCl. It is dried over Na2SO4 and then concentrated. The residue crystallizes from pentane and 3.3 g of the expected compound are obtained: m.p.=150-152° C.

1. waitthe mixture is then left
2. waitthe mixture is then left
3. stirringstirring for 6 hours at RT
4. concentrationThis mixture is concentrated under vacuum
5. washwashed with water, with saturated Na2CO3 solution, with sulphate buffer
6. dry with materialIt is dried over Na2SO4
7. concentrationconcentrated
8. customThe residue crystallizes from pentane and 3.3 g of the expected compound
9. customare obtained