1,1'-Carbonyldiimidazole → HCID 178474866, compound

HRID 846095Notes

Reaction equation

HRID 846095 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:15]2[CH2:16][CH2:17][C:18](=[O:21])[NH:19][N:20]=2)[CH:5]=[CH:6][C:7]=1[NH:8][CH2:9][CH2:10][NH:11][C:12](=[O:14])[CH3:13].[C:22](N1C=CN=C1)(N1C=CN=C1)=[O:23]>CN(C)C=O>[NH:11]([CH2:10][CH2:9][N:8]1[C:7]2[CH:6]=[CH:5][C:4]([C:15]3[CH2:16][CH2:17][C:18](=[O:21])[NH:19][N:20]=3)=[CH:3][C:2]=2[N:1]=[C:22]1[OH:23])[C:12]([CH3:13])=[O:14]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 15107813HCID 15107813, compound

Product 1

HCID 178474866HCID 178474866, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 580 mg (2.0 mmol) of 6-(3-amino-4-acetylaminoethylamino-phenyl)-4,5-dihydro-3(2H)-pyridazinone in 50 ml of dimethylformamide, 325 mg (2.0 mmol) of carbonyldiimidazole are added at 50° C. After 45 minutes at 50° C. the mixture is evaporated to dryness and the residue is mixed with 10 ml of water. The product precipitated is suction filtered, washed with 5 ml of water and dried.

Workup

  1. customAfter 45 minutes at 50° C. the mixture is evaporated to dryness
  2. additionthe residue is mixed with 10 ml of water
  3. customThe product precipitated
  4. filtrationfiltered
  5. washwashed with 5 ml of water
  6. customdried

Sources & evidence

ORD record
ord-0db611ed04a744f299d87a0822aa33c8
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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