反应详情

To a solution of 3-hydroxymethylbenzaldehyde (step 1) (3 g) in methylene chloride (15 mL) and triethylamine (4.1 mL) was slowly added t-butylchlorodiphenylsilane (8 mL). Finally, a few mgs of 4-pyrrolidinopyridine was added as a catalyst. The reaction mixture was stirred overnight at room temperature The solution was quenched with 25% ammonium acetate and extracted with ethyl acetate, which was washed with brine (2x), dried over sodium sulfate, filtered and evaporated to dryness. Purification by flash chromatography, using 4% ethyl acetate in hexane afforded the title compound.

1. customwas quenched with 25% ammonium acetate
2. extractionextracted with ethyl acetate, which
3. washwas washed with brine (2x)
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customevaporated to dryness
7. customPurification by flash chromatography