反应详情

After 14.6 g of concentrated sulfuric acid and 8.6 g (50 mmol) of (-)-2-methyldecanol were added to 96 ml of water, 16.4 g (10.4 mmol) of potassium permanganate was added dropwise over 4 hours while the reaction temperature was held below 25° C. The thus obtained reaction mixture was poured into 300 ml of ice water, added with 30 g of sodium hydrogen sulfite, adjusted to pH of not more than 1 with hydrochloric acid, extracted with ether and then extracted with a 10% aqueous solution of sodium hydroxide. This extract was added with hydrochloric acid to adjust pH to not more than 1 and again extracted with chloroform. The thus obtained extract was washed with water, dried, concentrated, and distilled under a reduced pressure (0.4 mmHg, 116°~120° C.) to obtain 5.2 g (yield 63%) of (+)-2-metyl decanoic acid.

1. additionwas added dropwise over 4 hours while the reaction temperature
2. customwas held below 25° C
3. customThe thus obtained reaction mixture
4. extractionextracted with ether
5. extractionextracted with a 10% aqueous solution of sodium hydroxide
6. additionThis extract was added with hydrochloric acid
7. extractionagain extracted with chloroform
8. customThe thus obtained
9. extractionextract
10. washwas washed with water
11. customdried
12. concentrationconcentrated
13. distillationdistilled under a reduced pressure (0.4 mmHg, 116°~120° C.)