反应详情

温度

0 °C

6.95 mL bromacetylbromide was dropped to 11.68 mL 1-pyridin-2-yl-piperazine and 11.23 mL triethylamine in 300 mL DCM at 0° C. The reaction was stirred 2 h at 0° C. The reaction mixture was added to water and extracted with DCM. The organic layer was dried with magesium sulfate and evaporated The residue was purified by chromatography on silica gel (DCM/MeOH 0-20%; 0.1% ammonia) to yield 23.6 g of the desired compound.

1. extractionextracted with DCM
2. dry with materialThe organic layer was dried with magesium sulfate
3. customevaporated The residue
4. customwas purified by chromatography on silica gel (DCM/MeOH 0-20%; 0.1% ammonia)