反应详情

0.38 mL methyl bromoacetate was added to 940 mg 2-cyclohexyl-4-(4-fluoro-3-methyl-phenyl)-1H-imidazole and 1.52 g potassium carbonate in 10 mL DMF. The reaction was stirred over night at RT and evaporated. Methanol and 1 mol/L sodiumhydroxide solution was added and the mixture was stirred 2 h at RT. The solvent was removed. The residue was dissolved in water and acidified with 1 mol/L HCL solution. The precipitate was filtered and dried to give 700 mg desired product. Rt: 0.92 min (method B), (M+H)+: 317

1. customevaporated
2. additionMethanol and 1 mol/L sodiumhydroxide solution was added
3. stirringthe mixture was stirred 2 h at RT
4. customThe solvent was removed
5. dissolutionThe residue was dissolved in water
6. filtrationThe precipitate was filtered
7. customdried