Potassium Carbonate → HCID 86686616, compound

HRID 84768Notes

Reaction equation

HRID 84768 reaction equation
Br[CH2:2][C:3]([O:5]C)=[O:4].[CH:7]1([C:13]2[NH:14][CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[C:20]([CH3:25])[CH:19]=3)[N:17]=2)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:7]1([C:13]2[N:14]([CH2:2][C:3]([OH:5])=[O:4])[CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[C:20]([CH3:25])[CH:19]=3)[N:17]=2)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 178422928HCID 178422928, compound

Product 1

HCID 86686616HCID 86686616, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.38 mL methyl bromoacetate was added to 940 mg 2-cyclohexyl-4-(4-fluoro-3-methyl-phenyl)-1H-imidazole and 1.52 g potassium carbonate in 10 mL DMF. The reaction was stirred over night at RT and evaporated. Methanol and 1 mol/L sodiumhydroxide solution was added and the mixture was stirred 2 h at RT. The solvent was removed. The residue was dissolved in water and acidified with 1 mol/L HCL solution. The precipitate was filtered and dried to give 700 mg desired product. Rt: 0.92 min (method B), (M+H)+: 317

Workup

  1. customevaporated
  2. additionMethanol and 1 mol/L sodiumhydroxide solution was added
  3. stirringthe mixture was stirred 2 h at RT
  4. customThe solvent was removed
  5. dissolutionThe residue was dissolved in water
  6. filtrationThe precipitate was filtered
  7. customdried

Sources & evidence

ORD record
ord-d2641bf05d10436e8a55ac9a398a7a56
Source dataset
uspto-grants-2014_09
Patent number
US08846948B2

Reaction notes

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