Hydrochloric Acid → 2,6-Difluorobenzene-1-carbothioamide

HRID 850032Notes

Reaction equation

HRID 850032 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].C(N(CC)CC)C.O.[S-2:19].[Na+].[Na+].Cl>N1C=CC=CC=1>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4](=[S:19])[NH2:5]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 746952,6-DifluorobenzonitrileHCID 19906495Sodium sulfide monohydrate

Product 1

HCID 126832122,6-Difluorobenzene-1-carbothioamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

As illustrated in step a of Scheme III, 2,6-difluorobenzonitrile is reacted with triethylamine, sodium sulfide hydrate, and hydrochloric acid in pyridine at room temperature to give 2,6-difluorobenzenethioamide.

Sources & evidence

ORD record
ord-6be143f784d94c6ba7b944dc54a39fb7
Source dataset
uspto-grants-2000_01
Patent number
US06015826

Reaction notes

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