反应详情

温度

90 °C

To a solution (10 ml) of ethyl 1-(3-cyano-4-hydroxyphenyl)pyrazole-4-carboxylate (1.5 g) in dimethylformamide were added potassium carbonate (0.91 g) and (S)-(+)-1-bromo-2-methylbutane (1 g) with stirring, and the mixture was heated at 90° C. for 2 hours. After the completion of the reaction, the reaction mixture was poured into water and the mixture was acted with ethyl acetate, washed with water and dried over magnesium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was recrystallized from isopropyl ether to give 1.7 g of ethyl 1-(3-cyano-4-((S)-2-methylbutoxy)phenyl)pyrazole-4-carboxylate, melting point 105-106° C.

1. customAfter the completion of the reaction
2. washwashed with water
3. dry with materialdried over magnesium sulfate
4. customThe solvent was evaporated under reduced pressure
5. customthe obtained residue was recrystallized from isopropyl ether