Hydrochloric Acid → HCID 20502541, compound

HRID 851119Notes

Reaction equation

HRID 851119 reaction equation
C([N:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][CH2:28][N:29]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[C:32](=[O:33])[C:30]2=[O:31])[CH2:22][CH2:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:40]>O1CCCC1>[ClH:40].[ClH:40].[N:23]1([CH2:26][CH2:27][CH2:28][N:29]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[C:32](=[O:33])[C:30]2=[O:31])[CH2:24][CH2:25][NH:20][CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20502506HCID 20502506, compound

Product 1

HCID 20502541HCID 20502541, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1-[3-(4-trityl-1-piperazinyl)propyl]isatin (5.0 g) in tetrahydrofuran (100 ml) was added all at once concentrated hydrochloric acid (5 ml) and the mixture was vigorously stirred for half an hour. The resultant precipitates were collected by filtration and washed with tetrahydrofuran to give 1-[3-(1-piperazinyl)propyl]isatin dihydrochloride (2.96 g).

Workup

  1. customThe resultant precipitates
  2. filtrationwere collected by filtration
  3. washwashed with tetrahydrofuran

Sources & evidence

ORD record
ord-ebefe7087524460ea98363bdf557de33
Source dataset
uspto-grants-1983_05
Patent number
US04382934

Reaction notes

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