反应详情

4-Chloro-N-(2-oxo-azepan-3-yl)-benzenesulfonamide (1.21 g, 4.00 mmol), 4-(bromomethyl)-benzonitrile (0.79 g, 4.00 mmol), potassium carbonate (5.58 g, 40.0 mmol) and potassium iodide (0.13 g, 0.80 mmol) in 200 ml dimethylformamide were stirred at 65° C. for 16 hours. Extraction with water/ethylacetate and chromatography on silicagel with ethylacetate yielded 1.05 g (63%) 4-chloro-N-(4-cyano-benzyl)-N-(2-oxo-azepan-3-yl)-benzenesulfonamide as white solid, MS: m/e (%)=418.1 (MH+, 100).

1. extractionExtraction with water/ethylacetate and chromatography on silicagel with ethylacetate