Potassium Iodide → HCID 17906270, compound

HRID 852097Notes

Reaction equation

HRID 852097 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:15]3[CH:16]=[CH:17][C:18]([F:20])=[CH:19][C:14]=3[O:13][N:12]=2)=[CH:7][CH:6]=1.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(#N)C>[F:20][C:18]1[CH:17]=[CH:16][C:15]2[C:11]([C:8]3[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:6][CH:7]=3)=[N:12][O:13][C:14]=2[CH:19]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 17906318HCID 17906318, compound

Product 1

HCID 17906270HCID 17906270, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared from a mixture of 3[4-(2-bromo-ethoxy)-phenyl]-6-fluoro-benzo[d]isoxazole, pyrrolidine, potassium carbonate, potassium iodide and 5% aqueous acetonitrile at 75° C. essentially as described above in Example 13, except that the column is eluted with 10% methanol in ethyl acetate. Purity by LC/MS=99%, [M+H]+=327.

Workup

  1. washis eluted with 10% methanol in ethyl acetate

Sources & evidence

ORD record
ord-37dac2efef8448fb92ee5bb3d9c6aea5
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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