Potassium Carbonate → HCID 69039384, compound

HRID 853163Notes

Reaction equation

HRID 853163 reaction equation
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]([CH2:12][CH3:13])[C:8]([NH:10][CH3:11])=[O:9])=[CH:4][CH:3]=1.Br[CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[C:22]([C:21]1[CH:24]=[CH:25][C:18]([CH2:17][O:1][C:2]2[CH:3]=[CH:4][C:5]([O:6][CH:7]([CH2:12][CH3:13])[C:8]([NH:10][CH3:11])=[O:9])=[CH:14][CH:15]=2)=[CH:19][CH:20]=1)#[N:23]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 869964-(Bromomethyl)benzonitrileHCID 69037912HCID 69037912, compound

Product 1

HCID 69039384HCID 69039384, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

In analogy to the procedure described in Example 3b), the alkylation of (RS)-2-(4-hydroxy-phenoxy)-N-methyl-butyramide with 4-bromomethyl-benzonitrile in 2-butanone using potassium carbonate as the base yielded the (RS)-2-[4-(4-cyano-benzyloxy)-phenoxy]-N-methyl-butyramide as a white solid; MS: m/e=325 (M+H)+.

Sources & evidence

ORD record
ord-bdcd0a9508df4cb8bd339336be8024f9
Source dataset
uspto-grants-2007_08
Patent number
US07253318B2

Reaction notes

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