反应详情

温度

70 °C

In 60 ml of 1-methyl-2-pyrrolidone were dissolved 10.0 g (72.36 mmol) of isophorone and 14.9 g (95.6 mmol) of 1-bromobutane. To this mixture was added 8.1 g (144.4 mmol) of powdered potassium hydroxide and the mixture was stirred with heating at 70° C. for 6 hours. After the reaction mixture was added to water, extraction with ethyl acetate, washing with a saturated saline solution, drying over anhydrous sodium sulfate, and concentration were performed. The residual liquid was purified by silica gel column chromatography to give 6.31 g of a yellow oily matter (yield: 44.9%).

1. washwashing with a saturated saline solution
2. dry with materialdrying over anhydrous sodium sulfate, and concentration
3. customThe residual liquid was purified by silica gel column chromatography
4. customto give 6.31 g of a yellow oily matter (yield: 44.9%)