Methanesulfonic Acid → HCID 22320670, compound

HRID 854440Notes

Reaction equation

HRID 854440 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[N:10]=[CH:11][O:12][C:13]=1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([CH:23]([CH3:25])[CH3:24])=[N:21][N:22]=2)[CH:19]=1.[CH3:26][S:27]([OH:30])(=[O:29])=[O:28]>C(O)(C)C>[CH3:26][S:27]([OH:30])(=[O:29])=[O:28].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[N:10]=[CH:11][O:12][C:13]=1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([CH:23]([CH3:25])[CH3:24])=[N:21][N:22]=2)[CH:19]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 9949821CP-863187

Product 1

HCID 22320670HCID 22320670, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

6-[4-(2,5-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine (5.10 g, 15 mmol) was dissolved in isopropanol (25 ml). A solution of methanesulfonic acid (1.44 g, 15 mmol) in isopropanol (15 ml) was added. The resulting slurry was stirred at room temperature for 3 hours and filtered. The cake was washed with isopropanol and dried in a vacuum oven (80° C.) for 4 hours. 6-[4-(2,5-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine methanesulfonate was obtained as an off-white powder (6.03 g, yield 92%).

Workup

  1. filtrationfiltered
  2. washThe cake was washed with isopropanol
  3. customdried in a vacuum oven (80° C.) for 4 hours

Sources & evidence

ORD record
ord-200f6019a4984a14b8a425dd2ea40b13
Source dataset
uspto-grants-2007_08
Patent number
US07259171B2

Reaction notes

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