反应详情

4-Nitro-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester (2.0 g, 8.83 mmol) was added to a solution of 2-ethoxyethyl bromide (1.18 mL, 10.45 mmol) and potassium carbonate (1.32 g, 9.56 mmol) in N,N-dimethylformamide (35 mL) and the reaction mixture stirred for 48 hours at room temperature. The reaction mixture was concentrated in vacuo and partitioned between ethyl acetate (200 mL) and water (100 mL). The organic layer was separated, dried over magnesium sulphate and concentrated in vacuo. The crude product was purified by column chromatography on silica gel eluting with pentane:ethyl acetate 100:0 to 70:30 to yield the title product, 1.63 g.

1. concentrationThe reaction mixture was concentrated in vacuo
2. custompartitioned between ethyl acetate (200 mL) and water (100 mL)
3. customThe organic layer was separated
4. dry with materialdried over magnesium sulphate
5. concentrationconcentrated in vacuo
6. customThe crude product was purified by column chromatography on silica gel eluting with pentane:ethyl acetate 100:0 to 70:30