Dichloromethane → HCID 21865599, compound

HRID 857293Notes

Reaction equation

HRID 857293 reaction equation
[CH3:1][S:2]([C:5]([C:8]1[CH:9]=[C:10]2[C:15](=[C:16]([C:18]3[CH:19]=[C:20]([CH:24]([N:26]([C:35]4[CH:40]=[CH:39][C:38]([S:41]([CH3:44])(=[O:43])=[O:42])=[CH:37][CH:36]=4)[C:27](=[O:34])C4C=CC=CC=4)[CH3:25])[CH:21]=[CH:22][CH:23]=3)[CH:17]=1)[N:14]=[CH:13][CH:12]=[CH:11]2)([CH3:7])[CH3:6])(=[O:4])=[O:3].[CH:45]([N:48]=C=O)([CH3:47])[CH3:46].C(Cl)Cl>CCOC(C)=O>[CH:45]([NH:48][C:27](=[O:34])[N:26]([CH:24]([C:20]1[CH:21]=[CH:22][CH:23]=[C:18]([C:16]2[CH:17]=[C:8]([C:5]([S:2]([CH3:1])(=[O:3])=[O:4])([CH3:7])[CH3:6])[CH:9]=[C:10]3[C:15]=2[N:14]=[CH:13][CH:12]=[CH:11]3)[CH:19]=1)[CH3:25])[C:35]1[CH:36]=[CH:37][C:38]([S:41]([CH3:44])(=[O:43])=[O:42])=[CH:39][CH:40]=1)([CH3:47])[CH3:46]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 61277Isopropyl isocyanateHCID 10312400HCID 10312400, compound

Product 1

HCID 21865599HCID 21865599, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared according to the procedure described in EXAMPLE 41 but using (1-{3-[6-(1-Methanesulfonyl-1-methyl-ethyl)-quinolin-8-yl]-phenyl}-ethyl)-(4-methylsulfanyl-phenyl)-amine (EXAMPLE 44, step 1) and iso-propyl isocyanate as the starting materials. Flash chromatography (CH2Cl2:EtOAc; 4:1) afforded the title compound as a foam.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4188a09a9d56410b9c7be31c43be7742
Source dataset
uspto-grants-2006_12
Patent number
US07144896B2

Reaction notes

Loading…