Hydrochloric Acid → HCID 10119804, compound

HRID 857428Notes

Reaction equation

HRID 857428 reaction equation
C[CH:2]([CH:6]1[C:10]2=[C:11]([S:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[C:12]3[C:13]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:14][C:15]([O:22][CH3:23])=[C:16]([S:18]([CH3:21])(=[O:20])=[O:19])[C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].O1CCOCC1.[Li+].[OH-].Cl>CO>[Cl:35][C:32]1[CH:33]=[CH:34][C:29]([S:28][C:11]2[C:12]3[C:13]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:14][C:15]([O:22][CH3:23])=[C:16]([S:18]([CH3:21])(=[O:19])=[O:20])[C:17]=3[N:9]3[CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:10]=23)=[CH:30][CH:31]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 312751,4-DioxaneHCID 131726157HCID 131726157, compound

Product 1

HCID 10119804HCID 10119804, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Step 1 was dissolved in MeOH (2 mL) and 1,4-dioxane (2 mL) and treated with 1N LiOH for 2 h at room temperature. Addition of 1N NaH2PO4 (3 mL) and 1N HCl (0.4 mL) led to a suspension that was filtered through paper. The solid was air dried overnight yielding 14 mg of the title compound as a white solid.

Workup

  1. filtrationwas filtered through paper
  2. customdried overnight

Sources & evidence

ORD record
ord-410eb699b19b441a92801064a441a7a8
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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