反应详情

A mixture of Boc-D-tert-butyl-alanine (74 mg, 0.30 mmol), (2S)-2-amino-N-[5-chloro-2-(1H-tetraazol-1-yl)benzyl]butanamide (99 mg, 0.30 mmol), HOAt (41 mg, 0.30 mmol), EDC (86 mg, 0.45 mmol), and Et3N (42 μL, 0.30 mmol) in DMF (1.0 mL) was stirred at rt overnight. A small amount of MeOH was added to aid in dissolution. Solvent was removed in vacuo to give the title compound, which was carried on directly to deprotection. LCMS (M+H): 522.0.

1. customSolvent was removed in vacuo