Dimethylformamide → 4-Bromo-2-chloromethyl-3,5-dimethylpyridine
Reaction equation
[Cl:1][CH2:2][C:3]1[C:8]([CH3:9])=[C:7](OC)[C:6]([CH3:12])=[CH:5][N:4]=1.P(Br)(Br)[Br:14].CN(C=O)C.[NH4+].[OH-]>>[Br:14][C:7]1[C:6]([CH3:12])=[CH:5][N:4]=[C:3]([CH2:2][Cl:1])[C:8]=1[CH3:9]Participants
Conditions
- Temperature
- 80 °C
Procedure
A suspension of 2-chloromethyl-4-methoxy-3,5-dimethyl-pyridine (3.24 g, 14.6 mmol) in PBr3 (8.0 ml, 85.1 mmol, 5.8 equiv.) was heated to 80° C. under nitrogen. A catalytic amount of DMF (0.50 ml, 6.4 mmol, 0.44 equiv.) was added, whereupon the suspension rapidly turned into an orange solution. After 40 min., the reaction was still incomplete as judged by HPLC. The temperature was raised to 110° C. and the reaction was prolonged for 30 min, at which point it was complete. The mixture was poured over ice, made basic with conc. aq. NH4OH and extracted into EtOAc. Washing with water, drying (brine, MgSO4) and concentration gave the title compound as a pink solid (1.51 g, 44%) containing 10% of an impurity by 1H-NMR. The crude was used without further purification. 1H-NMR (CDCl3) δ 8.19 (s, 1H), 4.59 (s, 2H), 2.48 (s, 3H), 2.37 (s, 3H).
Workup
- temperatureThe temperature was raised to 110° C.
- waitthe reaction was prolonged for 30 min, at which point it
- additionThe mixture was poured over ice
- extractionextracted into EtOAc
- washWashing with water
- customdrying
- concentration(brine, MgSO4) and concentration
Sources & evidence
- ORD record
- ord-fcd0b8a4e7704f17814f8f38a4bab1ed
- Source dataset
- uspto-grants-2006_12
- Patent number
- US07148228B2
Reaction notes
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