Hydrochloric Acid → 2-[4-(2-Cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-ylmethoxy)-2-fluoro-phenyl]-2-methyl-propionitrile

Temperature

0 °C

Sodium hydride (60%) (0.49 g, 12.3 mmol) was magnetically stirred in dry THF (33 mL) and cooled to 0° C. The mixture was then treated with Methyl acetoacetate (1.34 mL, 12.3 mmol) dropwise over 15 min. The reaction was allowed to stir for 30 min at 0° C. To the resulting clear solution was added nBuLi (1.6M in Hexanes) (7.71 mL, 12.3 mmol). The reaction was then allowed to stir for 30 min at 0° C. To the yellow solution was added 2-[4-(2-Cyclopentyl-2-oxo-ethoxy)-2-fluoro-phenyl]-2-methyl-propionitrile (1.19 g, 4.1 mmol) as a solution in dry THF (15 mL). The result was stirred at 0° C. for 15 min and then at room temperature for 90 min. The solution was next poured into 0.5N HCl (100 mL) and extracted with EtOAc (2×50 mL). The organics were concentrated and the residue dissolved in MeOH (33 mL) and treated with K2CO3 (1.5 g). The mixture was heated to 65° C. and maintained for 1 hr. The reaction was cooled and poured into 0.5N HCl (100 mL) and extracted with EtOAc (2×50 mL). The organics were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography (silica gel) eluting with CH2Cl2 through 1% MeOH in CH2Cl2 to yield the title compound as a white solid (1.21 g, 79%). 1H NMR (300 MHz, DMSO-d6) δ: 1.55 (m, 8 H), 1.69 (s, 6 H), 2.37 (m, 1 H), 2.62 (s, 2 H), 3.33 (s, 2 H), 4.10 (m, 2 H), 6.87 (m 2 H), 7.34 (m 1 H).

1. stirringto stir for 30 min at 0° C
2. stirringThe result was stirred at 0° C. for 15 min
3. waitat room temperature for 90 min
4. extractionextracted with EtOAc (2×50 mL)
5. concentrationThe organics were concentrated
6. dissolutionthe residue dissolved in MeOH (33 mL)
7. additiontreated with K2CO3 (1.5 g)
8. temperatureThe mixture was heated to 65° C.
9. temperaturemaintained for 1 hr
10. temperatureThe reaction was cooled
11. additionpoured into 0.5N HCl (100 mL)
12. extractionextracted with EtOAc (2×50 mL)
13. dry with materialThe organics were dried over Na2SO4
14. filtrationfiltered
15. concentrationconcentrated
16. customThe residue was purified by flash chromatography (silica gel)
17. washeluting with CH2Cl2 through 1% MeOH in CH2Cl2

ORD record

ord-14457561d5e442c4a17f92e19ac279b3

Source dataset

uspto-grants-2006_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07148226B2