Pyruvic Acid → HCID 85847975, compound

4-Trifluoromethylphenyl hydrazine (8.40 g, 47.7 mmol) was suspended in 1 N hydrochloric acid (130 ml) and fully stirred with a mechanical stirrer to obtain a suspension. A aqueous solution (50 ml) of pyruvic acid (4.20 g, 47.7 mmol) was added to the suspension and vigorously stirred to a mixture. 6 hours later, the mixture was extracted with ethyl acetate and washed with a saturated brine. The washed mixture was dried on sodium sulfate and then filtered. The residue obtained by concentrating the resulting filtrate was washed with a mixed solvent of hexane and chloroform (1:1) to obtain 2-(4-trifluoromethylphenyl hydrazono) propionic acid (10.47 g, 42.52 mmol, 89%). mp 190–191° C.; 1H NMR (400 MHz, CDCl3) δ 2.19 (3H, s), 7.23 (2H, d), 7.60 (2H, d), 7.87 (1H, brs).

1. customto obtain a suspension
2. stirringvigorously stirred to a mixture
3. extraction6 hours later, the mixture was extracted with ethyl acetate
4. washwashed with a saturated brine
5. customThe washed mixture was dried on sodium sulfate
6. filtrationfiltered
7. customThe residue obtained
8. concentrationby concentrating the resulting filtrate
9. washwas washed with a mixed solvent of hexane and chloroform (1:1)

ORD record

ord-fbe391bd5b01477d8d7ee2671e9dac45

Source dataset

uspto-grants-2006_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07153815B2