Water → HCID 19704248, compound

HRID 861547Notes

Reaction equation

HRID 861547 reaction equation
[CH2:1]([C:5]1[N:6](COCC[Si](C)(C)C)[C:7]2[C:13](=[O:14])[CH:12]([F:15])[CH2:11][S:10][C:8]=2[N:9]=1)[CH2:2][CH2:3][CH3:4].FC(F)(F)C(O)=O.O.C(=O)(O)[O-].[Na+]>ClCCl>[CH2:1]([C:5]1[NH:6][C:7]2[C:13](=[O:14])[CH:12]([F:15])[CH2:11][S:10][C:8]=2[N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 86752027HCID 86752027, compound

Product 1

HCID 19704248HCID 19704248, compoundYield 92.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

305 mg of the product of Stage B and 1.75 ml of trifluoroacetic acid were heated at 40° C. for 12 hours in 6.1 ml of dichloromethane. The mixture was poured into water, sodium bicarbonate was added until a pH of 6-7 was obtained. Extraction was carried out with methylene chloride and the solvent was eliminated under reduced pressure to obtain 180 mg of the expected product.

Workup

  1. additionwas added until a pH of 6-7
  2. customwas obtained
  3. extractionExtraction

Sources & evidence

ORD record
ord-59298bb53f4d4d5eb769ea9d646c77bd
Source dataset
uspto-grants-1998_02
Patent number
US05714508

Reaction notes

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