Iodoacetamide → HCID 8176846, compound

HRID 863252Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([N+:10]([O-:12])=[O:11])[CH:4]=1.C(=O)([O-])[O-].[K+].[K+].I[CH2:20][C:21]([NH2:23])=[O:22]>>[C:21]([CH2:20][O:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[N+:10]([O-:12])=[O:11])(=[O:22])[NH2:23]

Participants

Reactant 3

HCID 3727Iodoacetamide

HCID 11430Potassium Carbonate

HCID 15285Phenol, 4-methoxy-2-nitro-

Product 1

HCID 8176846HCID 8176846, compound

Procedure

Reaction of 1.41 g of 4-methoxy-2-nitrophenol, 3.04 g potassium carbonate and 3.61 g of iodoacetamide analogously to the process described in Example 55) gives 2-carbamoylmethoxy-5-methoxynitrobenzene: mp 190°-1° C.; Rf (O)=0.58; FAB-MS: (M+H)+ =227; anal. calc. for C9H10N2O5 : C47.79%, H4.46%, N12.38%; found C47.90%, H4.48%, N12.58%.

Sources & evidence

ORD record: ord-6b44def19dbc4b01b0907b0e022e3b85
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05719141

Reaction notes

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