1,1'-Carbonyldiimidazole → HCID 489442, compound

HRID 864440Notes

Reaction equation

HRID 864440 reaction equation
[CH3:1][O:2][C:3]1[C:11]([CH3:12])=[C:10]2[C:6]([CH:7]=[C:8]([C:13]([OH:15])=O)[NH:9]2)=[CH:5][CH:4]=1.C([C:18]1[C:19]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[N:20][CH:21]=[CH:22][CH:23]=1)C.C(N1C=CN=C1)([N:32]1[CH:36]=[CH:35]N=C1)=O>C1COCC1>[CH3:35][CH2:36][NH:32][C:18]1[CH:23]=[CH:22][CH:21]=[N:20][C:19]=1[N:24]1[CH2:25][CH2:26][N:27]([C:13]([C:8]2[NH:9][C:10]3[C:11]([CH3:12])=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=3[CH:7]=2)=[O:15])[CH2:28][CH2:29]1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 19418857HCID 19418857, compoundHCID 19418895HCID 19418895, compound

Product 1

HCID 489442HCID 489442, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the general procedure of EXAMPLE 16 and making non-critical variations but starting with 6-methoxy-7-methylindole-2-carboxylic acid (0.23 g), 1-(3-ethyl-2-pyridinyl)piperazine (0.24 g), 1,1'-carbonyldiimidazole (0.19 g) and THF (3 ml), the title compound is obtained, mp 162°-163°.

Sources & evidence

ORD record
ord-990f85339767410f8186017783431b21
Source dataset
uspto-grants-1996_10
Patent number
US05563142

Reaction notes

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