HRID864636

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7972

4-Methylmorpholine

C5H11NO

HCID19419592

未命名化合物

结构：N=C(NC(=O)OCc1ccccc1)c1ccc(-c2ncc(C(=O)O)cn2)cc1

HCID140376887

未命名化合物

PRODUCTS

生成物

结构：N=C(NC(=O)OCc1ccccc1)c1ccc(-c2ncc(C(=O)N3CCC(O)(CC(=O)OCc4ccccc4)CC3)cn2)cc1

HCID140376888

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared by reacting 2-[4-[N-(benzyloxycarbonyl)-amidino]-phenyl]-5-carboxy-pyrimidine with 1.2 equivalents of N,N-carbonyl-diimidazole in dimethylformamide at 5° C. followed by the addition of 1.2 equivalents of 4-[(benzyloxycarbonyl)-methyl]-4-hydroxy-piperidine-hydrochloride and 1.2 equivalents of N-methylmorpholine at ambient temperature.

WORKUP

后处理

customPrepared
customat 5° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-77dea8455d5f412599cce16b9445bfa6
来源数据集: uspto-grants-1996_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05563268
来源说明: uspto-grants-1996_10

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:25]=[CH:24][C:23]([C:26](O)=[O:27])=[CH:22][N:21]=2)=[CH:16][CH:15]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:30]([O:37][C:38]([CH2:40][C:41]1([OH:47])[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)=[O:39])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.CN1CCOCC1>CN(C)C=O>[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:21]=[CH:22][C:23]([C:26]([N:44]3[CH2:45][CH2:46][C:41]([CH2:40][C:38]([O:37][CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[O:39])([OH:47])[CH2:42][CH2:43]3)=[O:27])=[CH:24][N:25]=2)=[CH:16][CH:15]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1